Found these free apps the other day when looking for presentation support software.
One is called Desktop Curtain which displays a blank desktop right in front of your cluttered desktop.
The other application is called Plainview. Plainview is a full screen web browser.
Both are free and both work great. I am the type of user who does not like anything on my desktop but I still leave folders and files there that I am working on. Sometimes I just turn on the Desktop Curtain in order to “forget” about what it is I probably should be working on!